C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 227/32 (2006.01)
Patent
CA 2594494
The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives which are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of a prochiral beta amino acrylic acid derivative substrate in the presence of an ammonium salt and a transition metal precursor complexed with a chiral ferrocenyl diphosphine ligand.
La présente invention a trait à un procédé pour la préparation efficace de dérivés d'acides aminés bêta à enrichissement énantiomérique qui sont utiles dans la synthèse asymétrique de molécules biologiquement actives. Le procédé comprend une hydrogénation énantiosélective d'un substrat de dérivé d'acide acrylique d'acides aminés bêta prochiral en présence d'un sel d'ammonium et d'un précurseur de métal de transition complexé avec un ligand diphosphine ferrocényle chiral.
Armstrong Joseph D. III
Clausen Andrew M.
Krska Shane W.
Njolito Eugenia
Rivera Nelo R.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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