A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/14 (2006.01) C13B 30/02 (2011.01)
Patent
CA 2642504
The present invention relates to a process, for the production of crystalline particles of an active organic compound The process includes the steps of generating a micro-seed by a wet-milling process and subjecting the micro-seed to a crystallization process. The resulting crxystalline particles have a mean particle size of less than about 100 µm. The present invention also provides for a pharmaceutical composition which includes the crystalline particles produced by the method described herein and a pharmaceutically acceptable carrier.
Cette invention concerne un procédé servant à produire des particules cristallines d'un composé organique actif. Ce procédé comprend les étapes consistant à générer un micro-grain par un procédé de broyage humide puis à soumettre le micro-grain à un procédé de cristallisation. Les particules cristallines ainsi obtenues présentent une taille moyenne des particules inférieure à environ 100 µm. Cette invention concerne également une composition pharmaceutique qui renferme les particules cristallines produites par ce procédé et un excipient pharmaceutiquement acceptable.
Cote Aaron
Johnson Brian K.
Lee Ivan
Midler Michael
Starbuck Cindy
Dimock Stratton Llp
Merck & Co. Inc.
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