Processes for enhanced production of pantothenate

C - Chemistry – Metallurgy – 12 – P

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C12P 13/02 (2006.01) C07C 231/02 (2006.01) C07C 235/12 (2006.01) C12N 1/21 (2006.01) C12N 9/10 (2006.01) C12N 15/75 (2006.01) C12P 7/42 (2006.01)

Patent

CA 2434483

The present invention features improved methods for producing pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities. In particular, the invention features methods for reducing byproduct formation and increasing yields and purity of desired product. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.

La présente invention concerne des procédés améliorés de fabrication de pantoate et de pantothénate faisant intervenir des micro-organismes qui ont des activités enzymatiques biosynthétiques de pantothénate modifié. L'invention concerne en particulier des procédés permettant de réduire la formation de produits secondaires et d'augmenter les rendements et la pureté du produit recherché. Sont également décrits de micro-organismes de recombinaison et leurs conditions de culture. De plus, l'invention traite de compositions produites par de tels micro-organismes.

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