Procoagulant proteins derived from factor viii: c

Details Procoagulant proteins derived from factor viii: c Procoagulant proteins derived from factor viii: c

C - Chemistry, Metallurgy

12

N

530/13, 195/1.23

C12N 15/12 (2006.01) A61K 38/37 (2006.01) A61P 7/04 (2006.01) C07K 14/755 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1341174

Novel procoagulant proteins, derived from human Factor VIII: C, are disclosed which comprise the amino acid sequence: A-X-B wherein region A represents the polypeptide sequence Ala-20 through Arg-759 substantially as shown in Table l; region B represents the polypeptide sequence Ser-1709 through Tyr-2351 substantially as shown in Table 1; and region X represents a polypeptide sequence comprising up to 949 amino acids substantially duplicative of sequences of amino acids within the sequence Ser-760 through Arg-1708 of Table 1, wherein the amino terminus of X is covalently bonded through a peptide bond designated "-" to the carboxy terminus of A, and the carboxy terminus of X is likewise bonded to the amino terminus of B. Methods of making such proteins and their use in pharmaceutical preparations is also disclosed.

506408

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