C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 455/04 (2006.01) A61K 31/4745 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2644661
The instant invention relates to novel prodrugs of optically pure benzoquinolizine-2- carboxylic acid and pharmaceutical compositions that include the prodrugs. In particular, the present invention relates to the sulfonic acid salts of L-alanine and L- valine prodrugs of S-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-l-yl)-5-methyl-l-oxo-lH,5H-benzo[i,j] quinolizine-2-carboxylic acid. The compounds and compositions of the invention can be used to treat bacterial Gram-positive, Gram-negative and anaerobic infections, especially infections caused by resistant Gram-positive organism and Gram-negative organism, mycobacterial infections and emerging nosocomial pathogen infections.
La présente invention concerne de nouveaux promédicaments d'acide benzoquinolizine-2- carboxylique pur et des compositions pharmaceutiques comprenant les promédicaments. En particulier, la présente invention concerne des sels d'acide sulfonique de L-alanine et L- valine promédicaments de l'acide S-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-l-yl)-5-methyl-l-oxo-lH,5H-benzo[i,j] quinolizine-2-carboxylique. Les composés et compositions selon l'invention peuvent être utilisés pour traiter des infections bactériennes Gram-positif, Gram-négatif et anaérobies, des infections mycobactériennes et des infections pathogènes nosocomiales émergentes.
Desai Vijaya Narayan
Deshpande Prasad Keshav
Kale Rajesh Prabhakar
Patel Mahesh Vithalbhai
Yeole Ravindra Dattatrya
Desai Vijaya Narayan
Deshpande Prasad Keshav
Kale Rajesh Prabhakar
Patel Mahesh Vithalbhai
Smart & Biggar
LandOfFree
Prodrugs of benzoquinolizine-2-carboxylic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Prodrugs of benzoquinolizine-2-carboxylic acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Prodrugs of benzoquinolizine-2-carboxylic acid will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1854355