Prodrugs of imidazole derivatives, for use as proton pump...

Details Prodrugs of imidazole derivatives, for use as proton pump... Prodrugs of imidazole derivatives, for use as proton pump...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/4545 (2006.01) A61P 1/04 (2006.01) A61P 31/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2489361

An imidazole compound represented by the formula (I), a salt thereof and a compound of the formula (V), which is one of the intermediates thereof. wherein each symbol is as defined in the present specification. The compound of the present invention shows a superior anti-ulcer activity, a gastric acid secretion inhibitory action, a mucosa-protecting action, an anti-Helicobacter pylori action and the like. Since it shows low toxicity, the compound is useful as a pharmaceutical product.

Composé d'imidazole représenté par la formule (I), un de ses sels et composé représenté par la formule (V) et constituant l'un de ses intermédiaires. (I), (V) dans lesquelles chaque symbole est défini selon les revendications. Ce composé exerce une activité efficace anti-ulcère, une action inhibant la sécrétion de l'acide gastrique, une action de protection de la muqueuse, ainsi qu'une action anti-<i>Helicobacter pylori</i>. Etant donné que sa toxicité est réduite, ce composé est utile en tant que produit pharmaceutique.

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