C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4965 (2006.01) A61K 31/497 (2006.01) C07C 257/18 (2006.01) C07D 207/32 (2006.01) C07D 211/56 (2006.01) C07D 211/98 (2006.01) C07D 213/74 (2006.01) C07D 231/38 (2006.01) C07D 231/48 (2006.01) C07D 237/04 (2006.01) C07D 239/10 (2006.01) C07D 239/22 (2006.01) C07D 241/04 (2006.01) C07D 241/20 (2006.01) C07D 249/14 (2006.01) C07D 253/06 (2006.01) C07D 253/075 (2006.01) C07D 263/48 (2006.01) C07D 265/02 (2006.01) C07D 277/42 (2006.01) C07D 307/22 (2006.01) C07D 333/36 (2006.01) C07D
Patent
CA 2462601
The present invention relates to prodrug compounds, comprising a 5- or 6- membered heterocyclic or aromatic ring substituted with a derivatized amidine, as well as compositions and methods useful for preventing and treating thrombotic conditions in mammals. The prodrug compounds of the present invention selectively inhibit certain proteases of the coagulation cascade.
La présente invention concerne des composés promédicaments, qui comprennent un noyau hétérocyclique ou aromatique à 5 ou 6 chaînons substitué par un amidine dérivatisé, ainsi que des compositions et des méthodes utiles pour prévenir ou traiter des affections thrombotiques chez des mammifères. Les composés promédicaments de l'invention inhibent sélectivement certaines protéases de la cascade de la coagulation.
Case Brenda
Garland Danny J.
Hayes Michael J.
Huang Horng-Chih
Jones Darin E.
Pharmacia Corporation
Smart & Biggar
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