Production of biologically active proteins

Details Production of biologically active proteins Production of biologically active proteins

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A61K 39/00 (2006.01) C12N 15/79 (2006.01)

Patent

CA 2643200

A fusion protein that is expressed in a recombinant protein body-like assembly (RPBLA) in host eukaryotic cells and organisms is disclosed. More particularly, a biologically active polypeptide fused to a protein sequence that mediates the induction of RPBLA formation is expressed and accumulated in host cells after transformation with an appropriate vector. The eukaryotic host cell does not produce protein bodies in the absence of the fusion protein. Methods for preparing and using the RPBLAs and the fusion protein are also disclosed, as are nucleic acid molecules that encode the fusion proteins.

L'invention concerne une protéine de fusion qui est exprimée dans un assemblage recombinant analogue aux corpuscules protéiques (RPBLA, recombinant protein body-like assembly) dans des cellules et des organismes hôtes eucaryotes. Plus particulièrement, un polypeptide biologiquement actif fusionné à une séquence protéinique qui médie l'induction de la formation de RPBLA est exprimé et accumulé dans des cellules hôtes après transformation avec un vecteur approprié. La cellule hôte eucaryote ne produit pas de corpuscules protéiques en l'absence de la protéine de fusion. L'invention concerne également des procédés de préparation et d'utilisation des RPBLA et de la protéine de fusion, ainsi que des molécules d'acides nucléiques codant pour les protéines de fusion.

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