Production of bispecific molecules using polyethylene glycol...

Details Production of bispecific molecules using polyethylene glycol... Production of bispecific molecules using polyethylene glycol...

C - Chemistry, Metallurgy

07

K

C07K 14/46 (2006.01) C07K 16/12 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2499075

The invention relates to a bispecific molecule comprising a first recognition binding moeity that binds a Cab-like receptor cross-linked using a poly- (ethylene glycol) ("PEG") linker with one or more second recognition binding moieties that bind a molecule. The invention also relates to methods of producing such bispecific molecules and to therapeutic uses of such bispecific molecules.

L'invention concerne une molécule bispécifique comprenant une première fraction de liaison de reconnaissance qui lie un récepteur du type C3b réticulé au moyen d'un lieur poly-(éthylène glycol) ("PEG") à une ou plusieurs secondes fractions de liaison de reconnaissance qui se lient à une molécule. L'invention concerne également des méthodes de production de ces molécules bispécifiques et des utilisations thérapeutiques de ces molécules bispécifiques.

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