Production of dl-serine

C - Chemistry – Metallurgy – 07 – D

Patent

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260/526.1

C07D 203/08 (2006.01)

Patent

CA 1145359

ABSTRACT OF THE DISCLOSURE Production of DL-serine by heating a strong acid type cation exchange resin having aziridine-2-carboxylic acid absorbed thereto. Specifically, an industrial process for producing DL-serine is provided which comprises treating an alpha-halogeno-beta-aminopropionitrile or its mineral acid salt in water or a water-containing organic solvent with an alkali or alkaline earth metal hy- droxide to form an alkali or alkaline earth metal aziridine-2-carboxylate, treat- ing the reaction mixture with a strong acid type cation exchange resin to cause adsorption of aziridine-2-carboxylic acid, and thereafter heating the cation- exchange resin.

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