Production of humanized antibodies in transgenic animals

Details Production of humanized antibodies in transgenic animals Production of humanized antibodies in transgenic animals

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A01K 67/00 (2006.01) A61K 39/395 (2006.01) C07H 21/04 (2006.01) C07K 16/00 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01) C12N 15/66 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2422155

This invention relates to humanized antibodies and antibody preparations produced from transgenic non-human animals. The non-human animals are genetically engineered to contain one or more humanized immunoglobulin loci which are capable of undergoing gene rearrangement and gene conversion in the transgenic non-human animals to produce diversified humanized immunoglobulins. The present invention further relates to novel sequences, recombination vectors and transgenic vectors useful for making these transgenic animals. The humanized antibodies of the present invention have minimal immunogenicity to humans and are appropriate for use in the therapeutic treatment of human subjects.

Cette invention se rapporte à des anticorps humanisés et à des préparations d'anticorps produits à partir d'animaux non humains transgéniques. Les animaux non humains sont modifiés génétiquement de façon à contenir un ou plusieurs locus d'immunoglobulines humanisées qui sont capables de subir un réagencement des gènes et une conversion des gènes dans l'organisme des animaux non humains transgéniques, en vue de produire des immunoglobulines humanisées diversifiées. Cette invention concerne en outre des séquences, des vecteurs de recombinaison et des vecteurs transgéniques nouveaux, utiles pour produire ces animaux transgéniques. Les anticorps humanisés faisant l'objet de cette invention ont une immunogénicité minimale par rapport aux humains et ils sont appropriés pour servir dans le traitement thérapeutique de sujets humains.

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