Production process of .beta.-hydroxyamido acids

C - Chemistry – Metallurgy – 07 – D

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C07D 213/55 (2006.01) C07C 227/14 (2006.01)

Patent

CA 1185979

ABSTRACT A .beta.-hydroxyamino acid is produced by causing a strongly acidic ion-exchange resin to adsorb thereon aziridine-2-carboxylic acid or its derivative represented by the general formula (II): Image (II) wherein R1 represents a hydrogen atom, methyl group or a substituted or unsubstituted phenyl or pyridyl group, R2 means a hydrogen atom or a methyl group, and X is -CO2H, -CO2M(M: an alkali metal or alkaline earth metal), -CO2R3(R3: a lower alkyl group having 1-5 carbon atoms or an aralkyl group), -CONH2 or -CN, with a proviso that X is other than -CO2H and -CO2M when R1 and R2 are individually a hydrogen atom; and then heating the thus-adsorbed aziridine- 2-carboxylic acid or its derivative in the presence of water. The above process is employed to produce DL-serine, threonine, .beta.-hydroxyvaline, .beta.-hydroxyphenylalanine, etc.

403290

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