C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C12N 5/078 (2010.01) C07K 14/47 (2006.01) C07K 19/00 (2006.01) C12N 15/11 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/567 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2680549
Disclosed herein are methods and compositions for the treatment of cancer. In particular, the present invention identifies and characterizes the FANCI polypeptide as a vital component of the Fanconi anemia pathway and discloses inhibitors of FANCI and methods of using same. Such inhibitors are useful in inhibiting DNA damage repair and can be useful, for example, in the treatment of cancer.
Cette invention se rapporte à des procédés et des compositions utilisés dans le traitement du cancer. En particulier, l'invention repère et caractérise le polypeptide FANCI comme composant vital des voies de l'anémie de Fanconi, et décrit des inhibiteurs de FANCI et des procédés d'utilisation de ceux-ci. Ces inhibiteurs sont utilisés pour inhiber les altérations de l'ADN et peuvent être utilisés, par exemple, dans le traitement du cancer.
D'andrea Alan D.
Elledge Stephen J.
Hofmann Kay O.
Matsuoka Shuhei
Mogorzewska Agata M.
Borden Ladner Gervais Llp
Dana Farber Cancer Institute
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