Prolyl hydroxylase inhibitors and methods of use

Details Prolyl hydroxylase inhibitors and methods of use Prolyl hydroxylase inhibitors and methods of use

C - Chemistry, Metallurgy

07

D

C07D 213/81 (2006.01) A61K 31/4418 (2006.01) A61K 31/4427 (2006.01) A61K 31/4725 (2006.01) A61K 31/506 (2006.01) C07D 401/04 (2006.01) C07D 401/10 (2006.01) C07D 405/04 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2659682

The present disclosure relates to HIF-1.alpha. prolyl hydroxylase inhibitors of Formula I (see formula I) wherein R, R1, R2, R3, R a and I, are as defined in the description, compositions which comprise the HIF-1.alpha. prolyl hydroxylase inhibitors of Formula I and to methods for controlling, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia using the compounds of Formula I.

L'invention porte sur des inhibiteurs de la HIF-1.alpha. prolyl hydroxylase, sur des compositions renfermant lesdits inhibiteurs de la HIF-1.alpha. prolyl hydroxylase et sur des procédés permettant de maîtriser l'acrosyndrome, la coronaropathie, l'insuffisance cardiaque, l'ischémie et l'anémie.

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