C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) A01K 67/027 (2006.01) A61K 39/00 (2006.01) A61P 7/00 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2621917
It is intended to provide a promoter for inducing expression selectively and strongly in an immunocompetent cell and/or a blood cell such as a lymphocyte. In the invention, the object was achieved by finding that HHV6 MIE promoter, HHV7 MIE promoter and HHV7 U95 promoter unexpectedly induce a specific expression in an immunocompetent cell and/or a blood cell such as a T lymphocyte. By utilizing the promoters, a selective delivery of a DNA vaccine or the like can be realized.
L~invention a pour objet l~obtention d~un promoteur pour induire sélectivement et fortement une expression dans une cellule et/ou une cellule sanguine immunocompétente telle qu'un lymphocyte. L'objet de l'invention a été réalisé en découvrant qu~un promoteur HHV6 MIE, un promoteur HHV7 MIE et un promoteur HHV7 U95 induisent de façon inattendue une expression spécifique dans une cellule et/ou une cellule sanguine immunocompétente telle qu'un lymphocyte T. En utilisant les promoteurs, l~administration sélective d'un vaccin ADN ou similaire peut être réalisée.
Fuke Isao
Gomi Yasuyuki
Mori Yasuko
Takahashi Michiaki
Takemoto Masaya
Osler Hoskin & Harcourt Llp
The Research Foundation For Microbial Diseases Of Osaka Universi
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