C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2503475
Compositions and methods are disclosed for stimulating or inhibiting angiogenosis and/or cardiovascularization in mammals, including humans. pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac bypartrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present inventions fused to heterologous polypeptides sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Ashkenazi Avi J.
Baker Kevin P.
Ferrara Napoleone
Gerber Hanspeter
Goddard Audrey
Dennison Associates
Genentech Inc.
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