C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 17/02 (2006.01) A61P 27/02 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 14/52 (2006.01) C07K 16/18 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 7/00 (2006.01) C12N 9/99 (2006.01) C12N 15/09 (2006.01) C12N 15/11 (2006.01) C12N 15/86 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (200
Patent
CA 2376116
Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Cette invention se rapporte à des compositions et à des procédés servant à stimuler ou à inhiber l'angiogenèse et/ou la cardiovascularisation chez des mammifères, y compris l'homme. Ces compositions pharmaceutiques sont basées sur des polypeptides ou des antagonistes de ceux-ci, ayant été identifiés pour un ou plusieurs de ces usages. Les affections qui peuvent être diagnostiquées, prévenues ou traitées par ces compositions sont les lésions traumatiques telles que plaies, cancers divers et infections des vaisseaux telles que l'athérosclérose et l'hypertrophie cardiaque. Cette invention se rapporte en outre à de nouveaux polypeptides et à des molécules d'acide nucléique codant ces polypeptides, à des vecteurs et des cellules hôtes comprenant ces séquences d'acide nucléique, à des molécules de polypeptides chimériques comprenant ces polypeptides, fusionnées à des séquences de polypeptides hétérologues, et à des anticorps qui se lient à ces polypeptides, ainsi qu'à des procédés de production de ces polypeptides.
Ashkenazi Avi J.
Baker Kevin P.
Ferrara Napoleone
Gerber Hanspeter
Gerritsen Mary E.
Dennison Associates
Genentech Inc.
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