Prophylactic and/or therapeutic agent for functional dyspepsia

A - Human Necessities – 61 – K

Patent

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Details

A61K 35/74 (2006.01) A61P 1/00 (2006.01) A61P 1/10 (2006.01) A61P 1/14 (2006.01)

Patent

CA 2675729

It is found that a fermentation product from a propionibacterium shows a prophylactic and/or therapeutic effect on functional dyspepsia in an in vitro test and a test using a patient having irritable bowel syndrome. Specifically, it is found that the fermentation product has an activity of increasing the frequency of bowel contraction in a distal colorectum-specific manner without varying the force of bowel contraction, and it is also found that the fermentation product has an effect of improving the defecation, general abdominal condition or health-related QOL in a patient having irritable bowel syndrome. The fermentation product can be ingested in a large quantity. It is expected that the fermentation product has an effect of preventing/treating functional dyspepsia safely.

Le produit de fermentation faisant l'objet de la présente invention, issu d'une propionibactérie, s'est révélé être doté d'une activité prophylactique et/ou thérapeutique sur une dyspepsie fonctionnelle lors d'un essai in vitro et d'un essai sur un patient souffrant du syndrome du côlon irritable. De manière spécifique, il a été trouvé que le produit de fermentation est doté d'une activité permettant d'augmenter la fréquence de la contraction de l'intestin sans en modifier la force de contraction, et ce, selon un mode distal spécifique du côlon et du rectum. Il a également été trouvé que le produit de fermentation permet d'améliorer la défécation, la condition abdominale générale ou la qualité de vie (QDV) liée à la santé chez un patient atteint du syndrome du côlon irritable. Le produit de fermentation peut être ingéré en grande quantité. On s'attend à ce que le produit de fermentation permette de prévenir et de traiter une dyspepsie fonctionnelle en toute sécurité.

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