Propofol microdroplet formulations

Details Propofol microdroplet formulations Propofol microdroplet formulations

A - Human Necessities

61

K

A61K 31/05 (2006.01) A61K 9/107 (2006.01)

Patent

CA 2249375

Formulations of phospholipid-coated microdroplets of propofol devoid of fats and triglycerides provide chronic sedation over extended periods of time without fat overload. Being free of nutrients that support bacterial growth, these microdroplet formulations are bacteriostatic and bactericidal (e.g. self- sterilizing) and thus have extended shelf life.

Cette invention se rapporte à des formulations de microgouttelettes de propofol recouvertes de phospholipides, le propofol étant exempt de matières grasses et de triglycérides. Ces formulations assurent une sédation chronique sur des périodes prolongées sans surcharge en matières grasses. Etant donné qu'elles sont exemptes d'éléments nutritifs qui soutiennent la croissance bactérienne, ces formulations de microgouttelettes sont bactériostatiques et bactéricides (notamment auto-stérilisantes) et elles ont par conséquent une durée de conservation prolongée.

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