A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/557 (2006.01) A61K 9/00 (2006.01) A61K 31/5575 (2006.01) A61K 45/06 (2006.01) A61K 47/18 (2006.01) A61P 15/10 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61K 47/36 (2006.01)
Patent
CA 2395217
The invention provides methods of treating erectile dysfunction comprising the step of placing within the fossa navicularis of the patient an effective erection-inducing amount of a prostaglandin El composition of a semi-solid consistency. The composition comprises prostaglandin E1, a penetration enhancer, a polysaccharide gum, a lipophilic compound, and an acidic buffer system. The penetration enhancer is an alkyl-2-(N,N-disubstituted amino)- alkanoate ester, an (N,N-disubstituted amino)-alkanol alkanoate, or a mixture of these. The lipophilic compound may be an aliphatic Cl to C8 alcohol, aliphatic C2 to C30 ester, an aliphatic C8 to C30 ester, or a mixture of these. The composition includes a buffer system capable of providing a buffered pH value for said composition in the range of about 3 to about 7.4.
La présente invention concerne des procédés de traitement de dysérection comprenant une étape qui consiste à placer dans la fossette naviculaire du patient une quantité efficace pour induire une érection d'une composition de prostaglandine E1 de consistance semi-solide. La composition comprend: de la prostaglandine E1, un amplificateur de pénétration, une gomme glucidique, un composé lipophile, et un système tampon acide. L'amplificateur de pénétration est un ester d'alkyle-2-(N,N-disubstitué amino)-alcanoate, un (N,N-disubstitué amino)-alcanol alcanoate, ou un mélange de ceux-ci. Le composé lipophile peut être un alcool aliphatique en C1-C8, un ester aliphatique en C2-C30, un ester aliphatique en C8-C30, ou un mélange de ceux-ci. La composition comprend un système tampon capable de conférer une valeur pH tamponnée à ladite composition comprise entre environ 3 et environ 7,4.
Buyuktimkin Nadir
Buyuktimkin Servet
Yeager James
Mbm Intellectual Property Law Llp
Nexmed Holdings Inc.
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