Protease-containing cleaning compositions

Details Protease-containing cleaning compositions Protease-containing cleaning compositions

C - Chemistry, Metallurgy

11

D

C11D 3/386 (2006.01) A61K 8/22 (2006.01) A61K 8/23 (2006.01) A61K 8/24 (2006.01) A61K 8/41 (2006.01) A61K 8/42 (2006.01) A61K 8/46 (2006.01) A61K 8/49 (2006.01) A61K 8/66 (2006.01) A61Q 11/00 (2006.01) A61Q 11/02 (2006.01) A61Q 19/10 (2006.01) C12N 9/54 (2006.01)

Patent

CA 2173105

The present invention relates to cleaning compositions comprising protease enzyme which is a carbonyl hydrolase variant having an amino acid sequence not found in nature, which is derived by replacement of a plurality of amino acid residues of a precursor carbonyl hydrolase with different amino acids, wherein said plurality of amino acid residues replaced in the precursor enzyme correspond to position +76 in combination with one or more of the following residues: +99, +101, +103, +104, +107, +123, +27, +105, +109, +126, +128, +135, +156, +166, +195, +197, +204, +206, +210, +216, +217, +218, +222, +260, +265, and/or +274, where the numbered positions correspond to naturally-occurring subtilisin from Bacillus amyloliquefaciens or to equivalent amino acid residues in other carbonyl hydrolase or subtilisins (such as Bacillus lentus subtilisin).

La présente invention concerne des compositions de nettoyage contenant une enzyme protéolytique, qui est une carbonyle hydrolase modifiée ayant une séquence d'acides aminées que l'on ne trouve pas dans la nature et où on a remplacé une pluralité de groupes acides aminés de la carbonyle hydrolase initiale avec d'autres acides aminés. Ce remplacement d'acides aminés de l'enzyme initiale concerne l'acide aminé en position +76, ainsi qu'un ou plusieurs acides aminés dans les positions suivantes: +99, +101, +103, +104, +107, +123, +27, +105, +109, +126, +128, +135, +156, +166, +195, +197, +204, +206, +210, +216, +217, +218, +222, +260, +265 et/ou +274. Les positions numérotées des acides aminés correspondent à celles des acides aminés de la subtilisine naturelle de <u>Bacillus amyloliquefaciens</u> ou à celles d'autres carbonyle hydrolases ou subtilisines (par exemple subtilisine de <u>Bacillus lentus</u>).

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