Protease-derivatized cvf

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 9/64 (2006.01) A61K 47/48 (2006.01) C07K 14/46 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 11/02 (2006.01)

Patent

CA 2171532

A novel functionally active derivative of cobra venom factor is described in which the .beta.-chain has been cleaved by treatment with a protease. Gel-electrophoretic analyses of the purified derivative revealed the absence of an intact .beta.-chain and a decrease of the molecular weight.

L'invention concerne un nouveau dérivé fonctionnellement actif du facteur de venin de cobra dans lequel la beta -chaîne a été coupée par traitement avec une protéase. Des analyses par électrophorèse sur gel du dérivé purifié ont révélé l'absence d'une beta -chaîne intacte et une diminution du poids moléculaire.

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