Protease inhibitor peptides

Details Protease inhibitor peptides Protease inhibitor peptides

C - Chemistry, Metallurgy

12

N

C12N 15/15 (2006.01) A61K 38/57 (2006.01) C07K 14/47 (2006.01) C07K 14/81 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2330191

Analogues of the Kunitz Protease Inhibitor (KPI) domain of amyloid precursor protein bind to an inhibit activity of serine proteases, including kallikrein, plasmin and coagulation factors such as factors VIIa, IXa, Xa, XIa, and XIIa. Pharmaceutical compositions containing the KPI analogs, along with methods for using such compositions, are useful for ameliorating and treating clinical conditions associated with increased serine protease activity, such as blood loss related to cardiopulmonary bypass surgery. Nucleic acid sequences encoding these analogs and systems for expression of the peptides of the invention are provided.

L'invention concerne des analogues du domaine inhibiteur de protéase de Kunitz (KPI) de la protéine précurseur amyloïde qui se lient aux protéases sérines et inhibent l'activité de ces protéases, y compris la kallikréine, la plasmine et les facteurs de coagulation du type VIIa, IXa, Xa XIa et XIIa. L'invention concerne en outre des compositions pharmaceutiques renfermant des analogues de l'inhibiteur KPI, ainsi que des procédés relatifs à l'utilisation desdites compositions, utiles pour améliorer et traiter les états cliniques liés à une augmentation de l'activité de la protéase sérine, comme par exemple dans le cas des pertes sanguines inhérentes à une intervention chirurgicale avec circulation extra-corporelle. L'invention concerne enfin des séquences d'acides nucléiques codant les analogues considérés, et des systèmes permettant d'exprimer les peptides décrits dans l'invention.

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