Protease resistant insulin analogues

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/62 (2006.01) A61K 38/28 (2006.01) C12N 15/17 (2006.01)

Patent

CA 2663074

The present invention relates to novel insulin analogues exhibiting resistance towards protease, wherein at least two amino acids are substituted and/or deleted relative to the parent insulin molecule. A method for the preparation of such insulin analogues, insulin preparations containing the insulin analogues of the invention and a method of treating diabetes mellitus using these insulin analogues is also provided.

La présente invention concerne de nouveaux analogues de l'insuline présentant une résistance envers une protéase, dans lesquels au moins deux acides aminés sont substitués et/ou supprimés par rapport à la molécule d'insuline parente. L'invention concerne également un procédé pour la préparation de tels analogues de l'insuline, des préparations d'insuline contenant les analogues de l'insuline de l'invention, ainsi qu'un procédé pour traiter le diabète sucré à l'aide de ces analogues de l'insuline.

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