Proteasome inhibitors and methods of using the same

Details Proteasome inhibitors and methods of using the same Proteasome inhibitors and methods of using the same

C - Chemistry, Metallurgy

07

F

C07F 5/02 (2006.01) A61K 31/69 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2597273

The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly or indirectly with proteasome activity.

La présente invention concerne des composés d'acide boronique, des esters boroniques et des compositions associées qui permettent de moduler l'apoptose, comme par inhibition de l'activité du protéasome. Les composés et les compositions peuvent être utilisés dans des méthodes d'induction de l'apoptose et de traitement de maladies, telles que le cancer et d'autres troubles directement ou indirectement liés à l'activité du protéasome.

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