Protein delivery system using human papillomavirus...

A - Human Necessities – 61 – K

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A61K 39/12 (2006.01) A61K 48/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 14/025 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) C12N 15/37 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2339324

Human Papillomavirus virus like particles (VLPs) have been constructed so that they contain a modified L2 protein. The L2 protein has been minimized and is fused to a second protein or peptide. The fused protein is incorporated into the VLP and the VLP can deliver the protein to a cell. The modified VLPs can be used to increase the breadth of immune response in vaccine preparations or to deliver other proteins of interest.

Des particules humaines de type papillomavirus (VLP) ont été construites afin de renfermer une protéine L2 modifiée. La protéine L2 modifiée a été réduite et fusionnée en une seconde protéine ou un peptide. La protéine fusionnée est incorporée dans le VLP, et le VLP peut administrer cette protéine à une cellule. Les VLP modifiés peuvent être utilisés afin d'augmenter l'ampleur de la réponse immunitaire dans des préparations de vaccin ou d'administrer d'autres protéines considérées.

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