Protenoid carriers and methods for preparation and use thereof

Details Protenoid carriers and methods for preparation and use thereof Protenoid carriers and methods for preparation and use thereof

A - Human Necessities

61

K

A61K 47/42 (2006.01) A01N 25/28 (2006.01) A61K 8/04 (2006.01) A61K 8/64 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61Q 13/00 (2006.01) C07C 229/42 (2006.01) C07C 233/55 (2006.01) C07C 233/63 (2006.01) C07C 233/87 (2006.01) C07C 235/38 (2006.01) C07C 235/64 (2006.01) C07C 235/84 (2006.01) C07C 237/22 (2006.01)

Patent

CA 2164957

Improved proteinoid carriers and methods for their preparation and use as oral delivery systems for pharmaceutical agents are described. The proteinoid carriers are soluble within selected pH ranges within the gastrointestinal tract and display enhanced stability towards at least one of photolysis or decomposition over time. The proteinoid carriers are prepared from proteinoids having between 2 and 20 amino acids and having a molecular weight of between about 250 and 2400 daltons.

L'invention concerne des excipients proténoïdiques perfectionnés, ainsi que leurs procédés de fabrication et leur utilisation; ces excipients permettent de délivrer des agents pharmaceutiques par voie orale. Les excipients proténoïdiques sont solubles dans des conditions de pH sélectionnées, correspondant à celles existant dans le tube digestif, et sont plus résistants, dans le temps, à la photolyse ou à la décomposition, voire aux deux. Les excipients de proténoïdiques sont élaborés à partir de protéinoïdes contenant de 2 à 20 acides aminés et ayant une masse moléculaire allant de 250 à 2400 daltons environ.

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