Protocadherin proteins and their uses

Details Protocadherin proteins and their uses Protocadherin proteins and their uses

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2170156

Polynucleotide sequences encoding cadherin-like polypeptides, designed protocadherins, and variants thereof are provided by the invention as well as methods and materials for the recombinant production of the same. Antibody substances specific for protocadherins are also disclosed as useful for modulating the natural binding and/or regulatory activities of the protocadherins.

L'invention se rapporte à des séquences polynucléotidiques codant des polypeptides de type cadhérines, appelés protocadhérines, et à des variantes de ceux-ci, ainsi qu'à des procédés et matériaux s'appliquant à leur production par recombinaison. Des substances anticorpales spécifiques des protocadhérines sont également décrites et sont utilisées pour moduler la fixation naturelle et/ou les activités régulatrices des protocadhérines.

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