Pteridinone derivatives as pi3-kinases inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2677168

New compounds of Formula (1) are provided which by virtue of their pharmaceutical activity as PI3-kinase modulators may be used in the therapeutic field for the treatment of inflammatory or allergic diseases. Examples of these include inflammatory and allergic respiratory complaints, inflammatory diseases of the gastro-intestinal tract and motor apparatus, inflammatory and allergic skin diseases, inflammatory eye diseases, diseases of the nasal mucosa, inflammatory or allergic conditions involving autoimmune reactions or inflammations of the kidney.

L'invention concerne de nouveaux composés de formule (1) lesquels, en raison de leur activité pharmaceutique en tant que modulateurs des PI3-kinases, peuvent être utilisés dans le domaine thérapeutique pour le traitement de maladies inflammatoires ou allergiques. Les exemples de celles-ci comprennent des affections respiratoires inflammatoires et allergiques, des maladies inflammatoires du tractus gastro-intestinal et de l'appareil moteur, des maladies inflammatoires et allergiques de la peau, des maladies inflammatoires de l'AEil, des maladies de la muqueuse nasale, des affections inflammatoires ou allergiques mettant en jeu des réactions auto-immunes ou des inflammations du rein.

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