Pulmonary administration of chemically modified insulin

Details Pulmonary administration of chemically modified insulin Pulmonary administration of chemically modified insulin

A - Human Necessities

61

K

A61K 38/28 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01) A61K 38/00 (2006.01) A61K 38/16 (2006.01) A61K 47/10 (2006.01) A61K 47/30 (2006.01) A61K 47/48 (2006.01) A61P 3/08 (2006.01) A61P 5/48 (2006.01) A61P 5/50 (2006.01)

Patent

CA 2447236

The present invention provides active, hydrophilic polymer-modified derivatives of insulin. The insulin derivatives of the invention are, in one aspect, suitable for delivery to the lung and exhibit pharmakokinetic and/or pharmacodynamic properties that are significantly improved over native insulin.

L'invention concerne des dérivés d'insuline actifs et hydrophiles modifiés par polymères. Les dérivés d'insuline de l'invention conviennent, dans un de ces aspects, à une administration dans les poumons, et présentent des propriétés pharmacocinétiques et/ou pharmacodynamiques sensiblement améliorées par rapport à l'insuline naturelle.

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