C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 41/00 (2006.01)
Patent
CA 2526305
The invention relates to the pure d-(17.alpha.)-13-ethyl-17-hydroxy-18,19- dinorpregn-4-ene-~20-yne-3-one-3E-oxime isomer of formula (IA), the pure d- (17.alpha.)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yne-3-one-3Z-oxime isomer of formula (IB), which are of gestagen activity, as well as the process for the synthesis of the mixture of the above isomers and the pure isomers. The invention also relates to the pharmaceutical compositions - and the process for their synthesis - which contain either the pure isomer of formula (IA) or the pure isomer of formula (IB) as active ingredient as such or in combination with other active ingredients (for example an oestrogen agent) together with pharmaceutical auxiliary materials commonly used in practice.
L'invention concerne l'isomère pur de d-(17.alpha.)-13-éthyl-17-hydroxy-18,19-dinorpregn-4-èn-20-yn-3-one-3E-oxime de formule (IA), l'isomère pur de d-(17.alpha.)-13-éthyl-17-hydroxy-18,19-dinorpregn-4-èn-20-yn-3-one-3Z-oxime de formule (IB), présentant un effet gestagène, ainsi que des procédés pour réaliser la synthèse du mélange des isomères ci-dessus et des isomères purs. Elle concerne également des compositions pharmaceutiques - ainsi que leurs procédés de synthèse contenant soit l'isomère pur de formule (IA) soit l'isomère pur de formule (IB) comme principe actif, en tant que tel ou en combinaison avec d'autres principes actifs (par exemple un agent oestrogène) et d'autres substances auxiliaires pharmaceutiques utilisées habituellement dans la pratique.
Balogh Gabor
Horvath Janos
Keseru Gyoergy
Kozma Jozsef
Maho Sandor
Fetherstonhaugh & Co.
Richter Gedeon Vegyeszeti Gyar Rt.
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