Purine derivatives for use in the treatment of allergic,...

Details Purine derivatives for use in the treatment of allergic,... Purine derivatives for use in the treatment of allergic,...

C - Chemistry, Metallurgy

07

D

C07D 473/18 (2006.01) A61K 31/522 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 473/16 (2006.01)

Patent

CA 2733749

Compounds of formula (I): wherein R1 is C1-6alkylamino, C1-6alkoxy, or C3-7cycloalkyloxy; m is an integer having a value of 3 to 6; n is an integer having a value of 0 to 4; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

La présente invention concerne des composés de formule (I) : dans laquelle R1 représente un alkylamino en C1 à C6, un alcoxy en C1 à C6, ou un cycloalkyloxy en C3 à C7 ; m représente un entier ayant une valeur de 3 à 6 ; n représente un entier ayant une valeur de 0 à 4 ; et des sels de ceux-ci qui induisent l'interféron humain. Les composés qui induisent l'interféron humain peuvent être utiles dans le traitement de divers troubles, par exemple le traitement de maladies allergiques et autres états inflammatoires, par exemple la rhinite allergique et l'asthme, le traitement de maladies infectieuses et du cancer, et peuvent également être utiles comme adjuvants de vaccins.

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