C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/48 (2006.01) A61K 31/505 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01)
Patent
CA 2415486
Compounds of formula (I), wherein R1, p, R2, q, R3 and R4 are defined within, and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti-cell-proliferation) effect in a warm-blooded animal, such as man.
L'invention concerne des composés représentés par la formule (I), dans laquelle R?1¿, p, R?2¿, q, R?3¿ et R?4¿, ainsi que des sels acceptables sur le plan pharmaceutique, et des esters hydrolysable in vivo sont décrits. L'invention concerne également des procédés destinés à leur préparation et à leur utilisation en tant que médicaments, notamment des médicaments destinés à produire un effet inhibiteur du cycle cellulaire (anti-prolifération cellulaire) chez un animal à sang chaud, tel que l'homme.
Heaton David William
Newcombe Nicholas John
Thomas Andrew Peter
Astrazeneca Ab
Smart & Biggar
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