Pyranoindole and carbazole inhibitors of cox-2

Details Pyranoindole and carbazole inhibitors of cox-2 Pyranoindole and carbazole inhibitors of cox-2

C - Chemistry, Metallurgy

07

D

C07D 209/88 (2006.01) A61K 31/40 (2006.01) A61K 31/403 (2006.01) A61K 31/407 (2006.01) C07D 491/04 (2006.01) C07D 491/052 (2006.01)

Patent

CA 2261588

This invention provides compounds of formula (I) wherein R1, R2, R3 and R4 are, each, independently, hydrogen, alkyl, alkenyl, alkynyl, alkoxy, aralkoxy, trifluoroalkoxy, alkanoyloxy, hydroxy, halo, trifluoromethyl, cyano, amino, mono- or di-alkylamino, alkanamido, or alkanesulfonamido; R5 is hydrogen, alkyl, alkenyl, alkoxyalkyl or alkylcycloalkyl; R6 is hydrogen, alkyl or alkenyl; X is oxygen or carbon; A is oxygen or NZ; Z is hydroxyl, alkoxy, aryloxy, carboxyalkyloxy of 2-7 carbon atoms, arylamino, or alkylsulfonylamino of 1-6 carbon atoms; or a pharmaceutically acceptable salt thereof, which are useful in the treatment of arthritic disorders, colorectal cancer, and Alzheimer's disease.

Composés de la formule (I), dans laquelle R¿1?, R¿2?, R¿3? et R¿4? représentent chacun indépendamment hydrogène, alkyle, alcényle, alcynyle, alcoxy, aralcoxy, trifluoroalcoxy, alcanoyloxy, hydroxy, halo, trifluorométhyle, cyano, amino, mono- ou dialkylamino, alcanamido ou alcanesulfonamido; R¿5? est hydrogène, alkyle, alcényle, alcoxyalkyle ou alkylcycloalkyle; R¿6? est hydrogène, alkyle ou alcényle; X est oxygène ou carbone; A est oxygène ou NZ; Z est hydroxyle, alcoxy, aryloxy, carboxyalkyloxy comprenant 2 à 7 atomes de carbone, arylamino ou alkylsulfonylamino comprenant 1 à 6 atomes de carbone; ou sel pharmaceutiquement acceptable de ces composés, qui sont utiles dans le traitement d'affections arthritiques, du cancer colorectal et de la maladie d'Alzheimer.

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