A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/415 (2006.01) A61K 31/4152 (2006.01) A61K 31/4155 (2006.01) A61K 31/4178 (2006.01) A61K 31/427 (2006.01) A61K 31/454 (2006.01) A61K 31/53 (2006.01) A61K 31/5377 (2006.01) A61K 31/655 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2405408
Pharmaceutical compositions and compounds are provided. The compounds of the invention have anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, formulations of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical formulations are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative diseases, angiogenesis. The compounds of the invention are substituted pyrazoles and pyrazolines.
La présente invention concerne des compositions et des composés pharmaceutiques. Les composés de l'invention ont une action anti-proliférative et peuvent favoriser l'apoptose dans des cellules dans lesquelles la régulation normale du cycle et de la vie des cellules fait défaut. Dans une forme de réalisation de l'invention, on décrit des formulations des composés combinés à un support physiologiquement acceptable. Les formulations pharmaceutiques sont utiles dans le traitement des maladies hyperprolifératives, ces maladies incluant la croissance tumorale, les affections lymphoprolifératives et l'angiogenèse. Les composés selon l'invention sont des pyrazoles et des pyrazolines substitués.
Chafeev Mikhail A.
Costello Penelope C.
Daynard Timothy Scott
Leung Danny
Sanghera Jasbinder
Kinetek Pharmaceuticals Inc.
Smart & Biggar
Valocor Therapeutics Inc.
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