C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) C07D 213/00 (2006.01) C07D 215/00 (2006.01) C07D 231/00 (2006.01) C07D 231/24 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2401697
The present invention relates to compounds of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, A, X and Y are defined as in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as arthritis, colon cancer, and Alzheimer's disease in mammals, preferably humans, dogs, cats and livestock animals.
La présente invention concerne des composés représentés par la formule (I). Dans cette formule R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, A, X et Y sont définis dans les spécifications. Cette invention concerne aussi des compositions pharmaceutiques contenant ces composés et l'utilisation médicinale de celles-ci. Les composés de cette invention conviennent pour le traitement ou la réduction d'inflammations et d'autres inflammations associées à des pathologies, telles que l'arthrite, le cancer du colon et la maladie d'Alzeimer chez les mammifères, de préférence chez l'homme, le chien, le chat et le bétail,
Cheng Hengmiao
Dutra Jason Kenneth
Sakya Subas Man
Pfizer Products Inc.
Smart & Biggar
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