Pyrazolo[1,5-a]pyrimidine derivatives

Details Pyrazolo[1,5-a]pyrimidine derivatives Pyrazolo[1,5-a]pyrimidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 19/10 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2576949

Pyrazolo[1,5-a]pyrimidine derivatives of the formula (I) and pharmaceutically acceptable salts thereof exhibit excellent MAPKAP-K2 inhibiting activity. Consequently, pharmaceutical products comprising these as active ingredients are expected to be effective in the prevention or treatment of MAPKAP-K2 mediated diseases, for example, inflammatory diseases, autoimmune diseases, osteoclastic disorder, cancer and/or tumor growth.

L'invention concerne des dérivés de la pyrazolo[1,5-a]pyrimidine de formule (I) et des sels pharmaceutiquement acceptables de celle-ci et présentant une excellente activité d'inhibition de la MAPKAP-K2. Par conséquent, les produits pharmaceutiques contenant ceux-ci comme ingrédients actifs sont supposés être efficaces dans la prévention ou le traitement des maladies médiées par MAPKAP-K2, par exemple, les maladies inflammatoires, les maladies auto-immunes, l~affection ostéoclastique, les cancers et/ou la croissance l tumorale.

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