Pyrazolopyridines as kinase inhibitors

Details Pyrazolopyridines as kinase inhibitors Pyrazolopyridines as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4162 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2711741

Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and phar- maceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated patho-logical conditions are disclosed.

L'invention concerne des composés de formule (I) qui s'utilisent pour l'inhibition de CHK1 et/ou CKH2. Des procédés d'utilisation des composés de formule (I) et des stéréo-isomères et des sels de qualité pharmaceutique de ceux-ci, pour un diagnostic, une prévention ou un traitement in vitro, in situ et in vivo de tels troubles dans des cellules de mammifère ou d'affections pathologiques associées, sont également décrits.

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