Pyridazinone derivatives as cdk2-inhibitors

Details Pyridazinone derivatives as cdk2-inhibitors Pyridazinone derivatives as cdk2-inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/496 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) C07D 237/14 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2518917

The present invention relates to novel pyridazinone derivatives of the general formula (I), wherein A is A1 or A2; O A1= ~,N~R A2= NH R H O R is unsubstituted or at least monosubstituted C1-C10-alkyl, aryl, aryl (C1-C10- alkyl)-, heteroaryl, heteroaryl-(C1-C10-alkyl)-, heterocyclyl, heterocyclyl- (C1,-C10-alkyl)-, C3-C10-cycloalkyl, polycycloalkyl, C2-Cio alkenyl or C2-C10- alkinyl and Ar is unsubstituted or at least monosubstituted aryl or heteroaryl.

La présente invention concerne de nouveaux dérivés de pyridazinone de formule générale (I), dans laquelle A représente A1 ou A2 ; R représente alkyle en C¿1?-C¿10?, aryle, aryl-(C¿1?-C¿10?-alkyle), hétéroaryle, hétéroaryl-(C¿1?-C¿10?-alkyle), hétérocyclyle, hétérocyclyl-(C¿1?-C¿10?-alkyle), cycloalkyle en C¿3?-C¿10?, polycycloalkyle, alcényle en C¿2?-C¿10? ou alcynyle en C¿2?-C¿10? non substitué ou au moins monosubstitué et Ar représente aryle ou hétéroaryle non substitué ou au moins monosubstitué.

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