Pyridazinone derivatives as gsk-3beta inhibitors

Details Pyridazinone derivatives as gsk-3beta inhibitors Pyridazinone derivatives as gsk-3beta inhibitors

C - Chemistry, Metallurgy

07

D

C07D 237/24 (2006.01) A61K 31/50 (2006.01) A61P 25/00 (2006.01) C07D 237/14 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 409/04 (2006.01) C07D 409/14 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2506022

The present invention relates to novel pyridazinone derivatives of the general formula (I) wherein A is A1 or A2; R is unsubstituted or at least monosubstituted C1-C10-alkyl, aryl, aryl (C1-C10-alkyl)-, heteroaryl, heteroaryl-(C1-C10-~alkyl)-, heterocyclyl, heterocyclyl-(C1-C10-alkyl)-, C3- C10-cycloalkyl, polycycloalkyl, C2-C10 alkenyl or C2-C10-alkinyl and Ar is unsubstituted or at least monosubstituted aryl or heteroaryl.

Nouveaux dérivés de pyridazinones de formule générale (I) dans laquelle A représente A1 ou A2, R représente alkyle C¿1?-C¿10? non substitué ou au moins monosubstitué, aryle, aryl-(alkyle C¿1?-C¿10?), hétéroaryle, hétéroaryl-(alkyle C¿1?-C¿10?), hétérocyclyle, hétérocyclyl-(alkyle C¿1?-C¿10?), cycloalkyle C¿3?-C¿10?, polycycloalkyle, alcényle C¿2?-C¿10? ou alcynyle C¿2?-C¿10? et Ar représente aryle ou hétéroaryle non substitué ou au moins monosubstitué.

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