C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 237/18 (2006.01) A61K 31/50 (2006.01) C07D 237/14 (2006.01) C07D 237/24 (2006.01) C07D 237/28 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2340230
A pyridazinone derivative represented by formula (I): (see formula I) {wherein R1 represents a phenyl group, a substituted phenyl group, an aromatic heterocyclic group or a substituted aromatic heterocyclic group; R2 represents a(C1-C8)alkyl group, a substituted (C1-C8)alkyl group, a phenyl group, a substituted phenyl group, an aralkyl group, a substituted aralkyl group, an aromatic heterocyclic group, a substituted aromatic heterocyclic group, an amino group, an amino group substituted with one or two (C1-C8) alkyl groups which are the same or different, a 4- to 10-membered cyclic amino group, a cyano group, a carboxyl group, a (C1-C8)alkoxycarbonyl group, a carbamoyl group, a thiocarbamoyl group, an aminocarbonyl group, an aminocarbonyl group substituted with one or two (C1-C8) alkyl groups or substituted (C1-C8) alkyl groups which are the same or different, a 4- to 10-membered cyclic aminocarbonyl group, a phenylaminocarbonyl group, a substituted phenylaminocarbonyl group, an aromatic heterocyle-aminocarbonyl group or a substituted aromatic heterocyle-aminocarbonyl group; R3 represents a hydrogen atom, a(C1-C8) alkyl group, a substituted (C1-C8) alkyl group, a phenyl group, a substituted phenyl group, an aromatic heterocyclic group or a substituted aromatic heterocyclic group; and R9 represents a cyano group, (see formula II, III or IV) a pharmaceutically acceptable salt thereof, or a derivative thereof, or a pharmaceutical composition comprising as an active ingredient the derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent.
L'invention concerne des dérivés de pyridazinone représentés par la formule générale (1), y compris leurs sels médicalement acceptables, ainsi que des compositions médicamenteuses dans lesquelles les produits en question tiennent lieu de principe actif. Dans ladite formule, R<1> est phényle éventuellement substitué ou un groupe aromatique hétérocyclique; R<2> est aralkyle, phényle ou alkyle éventuellement substitué, un groupe aromatique hétérocyclique, amino, amino cyclique, cyano, carboxyle ou autre; R<3> est hydrogène, phényle ou alkyle éventuellement substitué ou un groupe aromatique hétérocyclique; et R<4> est cyano, carbonyle ou autre.
Gotoh Makoto
Nagamine Masashi
Onishi Masanobu
Oshita Yoshitami
Satoh Akiyuki
Nihon Nohyaku Co. Ltd.
Riches Mckenzie & Herbert Llp
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