C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/00 (2006.01) A61K 31/435 (2006.01) A61K 31/47 (2006.01) C07D 219/00 (2006.01)
Patent
CA 2545786
The present invention is directed to a method of use of triazolo-pyridazine compounds in the treatment of neuropathic pain. The present invention is also directed to the use of triazolo-pyridazine compounds in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson~s disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders - such as shift-work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal and other diseases. The present invention is also directed to novel triazolo-pyridazine compounds that selectively bind to .alpha.2.delta.-1 subunit of Ca channels.
La présente invention concerne une méthode d'utilisation de composés de triazolo-pyridazine pour le traitement de la douleur neuropathique. Elle concerne également l'emploi de tels composés pour le traitement de troubles psychiatriques et de l'humeur tels que schizophrénie, anxiété, dépression, troubles bipolaires, et panique, ainsi que le traitement de la douleur, la maladie de Parkinson, les dysfonctionnement cognitifs, l'épilepsie, les troubles des rythmes circadiens de du sommeil (tels que ceux induits par le travail posté ou le décalage horaire, la pharmacodépendance, la toxicomanie, les symptômes de sevrage et autres pathologies. La présente invention concerne de nouveaux composés de triazolo-pyridazine qui se lient sélectivement à la sous-unité ?¿2??-1 des canaux calcium.
Boueres Julia K.
Lim Jongwon
Munoz Benito
Pracitto Richard
Stock Nicholas
Merck & Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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