Pyridine and pyrazine derivatives as mnk kinase inhibitors

Details Pyridine and pyrazine derivatives as mnk kinase inhibitors Pyridine and pyrazine derivatives as mnk kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/497 (2006.01) A61K 31/5377 (2006.01) C07D 241/10 (2006.01) C07D 401/04 (2006.01) C07D 403/14 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2654358

The present invention relates to compounds of the general formula (I) wherein X, Y, Z, A, Ar, R1, R2, R3, and R4 are as defined herein, which compounds are inhibitors of MNK2 and MNK1. The invention also relates to the use of the compounds in therapy, pharmaceutical compositions comprising the compounds, and the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of disorders related to undesired activity of MNK1 and/or MNK2 kinases.

La présente invention concerne des composés de formule (I) dans laquelle X, Y, Z, A, Ar, R1, R2, R3 et R4 sont spécifiés dans la description, lesdits composés étant des inhibiteurs de la MNK2 et de la MNK1. L'invention concerne également l'utilisation des composés lors d'une thérapie, des compositions pharmaceutiques comprenant les composés et l'utilisation des composés dans la préparation d'un médicament destiné à la prophylaxie et au traitement de troubles liés à une activité non souhaitée des kinases MNK1 et/ou MNK2.

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