Pyridopyrimidinones

Details Pyridopyrimidinones Pyridopyrimidinones

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2545558

The invention relates to compounds of formula (I) wherein R1, R2 , R3 , R4 , R5, R6 , R7 , R8, R9, X and X' have the designations cited in patent claim 1. Said compounds are inhibitors of tyrosine kinases, especially TIE-2, and Raf kinases, and can, inter alia, be used for the treatment of tumours.

L'invention concerne des composés de formule (I), dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, R?9¿, X et X' ont les significations indiquées dans la revendication n· 1. Ces composés constituent des inhibiteurs des tyrosine kinases, en particulier TIE-2, et des kinases Raf et ils peuvent être utilisés notamment en traitement de tumeurs.

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