C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/65 (2006.01) A61K 31/4545 (2006.01) A61K 31/4709 (2006.01) A61K 31/4725 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) A61P 13/00 (2006.01) A61P 25/00 (2006.01) A61P 43/00 (2006.01) C07D 213/80 (2006.01) C07D 213/82 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2598294
To provide a compound usable for treatment of diseases associated with fatty acid amid hydrolase (FAAH), especially for treatment of urinary frequency and urinary incontinence, overactive bladder and/or pain. We have found that a novel pyridyl non-aromatic nitrogen-containing heterocyclic 1- carboxylate derivative and its pharmaceutically acceptable salt of formula III (see formula III) has a potent FAAH-inhibitory activity. Further, the pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate derivative of the present invention has an excellent effect for increasing an effective bladder capacity, an excellent effect for relieving urinary frequency and an excellent anti-allodynia effect, and is therefore usable for treatment of urinary frequency and urinary incontinence, overactive bladder and/or pain.
Le problème à résoudre dans le cadre de la présente invention concerne un composé qui peut être utilisé pour le traitement d'une maladie associée à une hydrolase des amides d'acide gras (FAAH), notamment la pollakiurie / l~incontinence urinaire, la vessie hyperactive et / ou la douleur. La solution proposée consiste en un nouveau dérivé d~ester de 1-carboxylate hétérocyclique azoté non-aromatique de pyridyle et un sel pharmaceutiquement acceptable de celui-ci présentant une activité inhibitrice FAAH puissante. Le dérivé est supérieur en termes d~augmentation de la capacité réelle de la vessie et d~amélioration de la pollakiurie et présente un effet antiallodynique. Par conséquent, ce composé peut être utilisé pour le traitement de la pollakiurie / de l~incontinence urinaire, de la vessie hyperactive et/ou de la douleur.
Ishii Takahiro
Kakefuda Akio
Kanai Chisato
Kanayama Takatoshi
Maeda Jun
Astellas Pharma Inc.
Dennison Associates
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