Pyrimidin-4-one derivatives and their use as p38 kinase...

Details Pyrimidin-4-one derivatives and their use as p38 kinase... Pyrimidin-4-one derivatives and their use as p38 kinase...

C - Chemistry, Metallurgy

07

D

C07D 239/52 (2006.01) A61K 31/513 (2006.01) C07D 239/46 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 403/10 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2521081

Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

L'invention concerne des composés répondant à la formule (I), et leurs sels pharmaceutiquement acceptables. Dans cette formule, R1, R2, R4, et R5, sont tels que définis ci-après. Ces composés sont utiles pour traiter des maladies et des infections provoquées ou exacerbées par une activité non régulée de la protéine-kinase associée aux membranes p38 et/ou du facteur de nécrose tumorale. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés, des procédés pour préparer ces derniers, ainsi que des méthodes de traitement les utilisant.

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