Pyrimidine compounds, compositions and methods of use

Details Pyrimidine compounds, compositions and methods of use Pyrimidine compounds, compositions and methods of use

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61K 31/529 (2006.01) A61K 31/5377 (2006.01) A61K 31/5383 (2006.01) A61K 31/55 (2006.01) A61P 35/00 (2006.01) C07D 471/04 (2006.01) C07D 471/14 (2006.01) C07D 471/18 (2006.01) C07D 498/14 (2006.01)

Patent

CA 2729045

Disclosed are compounds of Formula I, including steroisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR).

L'invention concerne des composés de la formule I, comprenant des stéréo-isomères, des isomères géométriques, des tautomères, des solvats, des métabolites et des sels pharmaceutiquement acceptables de ceux-ci, qui sont utiles pour moduler une signalisation de kinase en rapport avec PIKK, par exemple mTOR, et pour le traitement de maladies (par exemple le cancer) qui sont favorisées au moins en partie par la dérégulation du trajet de signalisation de PIKK (par exemple mTOR).

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