C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/54 (2006.01) A61K 31/505 (2006.01) A61P 31/12 (2006.01) C07D 239/557 (2006.01) C07D 409/04 (2006.01) C07D 417/04 (2006.01)
Patent
CA 2473508
A class of pyrimidinone derivatives of formula (I): wherein Z, R1, R2 and R3 are as defined herein; and pharmaceutically acceptable salts thereof; are inhibitors of viral polymerases, especially the hepatitis C virus (HCV) polymerase enzyme.
L'invention concerne des dérivés pyrimidone de formule (I), Z, R<sp>1</sp>, R<sp>2</sp> et R<sp>3</sp> ayant les significations données dans le descriptif, ainsi que des sels pharmaceutiquement acceptables desdits dérivés. Les composés selon l'invention sont des inhibiteurs de polymérases virales, notamment de l'enzyme polymérase du virus de l'hépatite C.
Avolio Salvatore
Colarusso Stefania
Conte Immacolata
Giulio Matassa Victor
Harper Steven
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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