Pyrimidyl cyclopentanes as akt protein kinase inhibitors

Details Pyrimidyl cyclopentanes as akt protein kinase inhibitors Pyrimidyl cyclopentanes as akt protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 239/70 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2692506

The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

La présente invention porte sur des composés de formule (I), comprenant les tautomères, les énantiomères résolus, les diastéréomères, les solvates, les métabolites, les sels et les promédicaments pharmaceutiquement acceptables de ces composés. L'invention porte également sur des procédés d'utilisation des composés de cette invention comme inhibiteurs de la protéine kinase Akt et pour le traitement de maladies hyperprolifératives telles que le cancer.

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