C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/14 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/506 (2006.01) A61P 31/04 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01)
Patent
CA 2732618
The present invention provides DNA Gyrase and/or Topo IV inhibitors of Formula (I), which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed by gram positive, gram negative and anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Pseudomonus spp., Acenetobacter spp., Muraxalla spp., Chlamydia spp., Mycoplasma spp., Legionella spp., Mycobacterium spp., Helicobacter, Clostridium spp., Bacteroides spp., Cotynebacterium, Bacillus spp., Enterobactericeae (E.coli, Klebsiella spp., Proteus spp.,etc. ) or any combination thereof. Also provided, are processes for preparing compounds disclosed herein, pharmaceutical compositions containing compounds disclosed herein, and methods of treating bacterial infections.
La présente invention porte sur des inhibiteurs de l'ADN Gyrase et/ou Topo IV de formule I, qui peuvent être utilisés comme agents antibactériens. Les composés décrits ici peuvent être utilisés pour le traitement ou la prévention d'états qui sont provoqués par ou auxquels contribuent les bactéries Gram positif, Gram négatif et anaérobies, plus particulièrement à l'encontre, par exemple, de Staphylococci, Streptococci, Enterococci, Haemophilus, Pseudomonus spp, Acenetobacter spp., Moraxalla spp., Chlamydia spp., Mycoplasma spp., Legionella spp., Mycobacterium spp., Helicobacter, Clostridium spp., Bacteroides spp., Corynebacterium, Bacillus spp., Enterobactericeae (E.coli, Klebsiella spp., Proteus spp., etc.) ou toute combinaison de ces bactéries. L'invention porte également sur des méthodes de préparation des composés décrits ici, sur des compositions pharmaceutiques contenant les composés décrits ici, et sur des méthodes de traitement d'infections bactériennes.
Ahmed Shahadat
Bhatnagar Pradip Kumar
Cliffe Ian A.
Ghosh Sanjay
Kulkarni Rakesh Dinkar
Dimock Stratton Llp
Ranbaxy Laboratories Limited
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